https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology presents An array of opportunities to contribute to biology. Right here I will current examples the place nanofabrication – the ability to make confined structures with dimensions at will – is utilized to examine the biophysics of single molecules and cells. I will present some examples from our lab:
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, Groningen scientists existing the effects in their endeavours to make labs much more sustainable and provide tips for other labs.
Sad to say, For many years just after Iijima’s report, the manufacture of clean up nanotubes was cumbersome. In 1996, nonetheless, the team of Richard Smalley at Rice University managed to make single-walled carbon nanotubes at substantial generate. Shortly immediately after, I contacted Smalley, and we decided to be part of forces to evaluate the transport by way of a one carbon nanotube.
We acquire position-of-care diagnostics test of neglected tropical diseases within just source-constrained settings, based on Crspr/Cas9 detecting of pathogen’s DNA in system fluids.
The coiled-coil in the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
Considering the fact that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his exploration has focused on studying mobile division with germs on chip, while his top fascination is within the way of noticing synthetic cells.
Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
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Right now, we also recognized that it should be feasible to make use of just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched particular person semiconducting nanotubes throughout metallic electrodes and employed the underlying silicon substrate as being a gate electrode, setting up the basic a few-terminal structure of the discipline-impact transistor (Fig.
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2001, discovery of solitary-electron transistors at area temperature based upon nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular construction of DNA fix enzymes with AFM
2008, 1st observation of protein-coated DNA translocation by way of nanopores; settled the origin on the electrophoretic power on DNA in nanopores; identified a major velocity boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes